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- Title
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
- Authors
Oliver, A W; He, X; Borthwick, K; Donne, A J; Hampson, L; Hampson, I N
- Abstract
Guanidine exchange factor (GEF)-catalysed activation of Rho proteins such as Cdc42 has been shown to have a crucial role in cellular transformation, malignant progression and invasion. We have previously shown that the HPV16 E6 oncoprotein binds to the PDZ domain protein Tax-interacting-protein 1 (Tip-1) and we now report identification and functional analysis of a novel Tip-1 binding GEF.
- Publication
British journal of cancer, 2011, Vol 104, Issue 2, p324
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6606026