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- Title
Molecular disruption of NBS1 with targeted gene delivery enhances chemosensitisation in head and neck cancer.
- Authors
Araki, K; Yamashita, T; Reddy, N; Wang, H; Abuzeid, W M; Khan, K; O'Malley, B W, Jr; Li, D
- Abstract
a fibroblast growth factor 2 (FGF2)-targeted adenoviral system can alter viral tropism and allow for improved transduction and reduced systemic toxicity. This study is to investigate if the FGF2-targeted adenoviral mutant Nijmegen breakage syndrome 1 (FGF2-Ad-NBS1) gene transfer can enhance cisplatin chemosensitisation not only by targeting DNA repair, but also through the induction of antiangiogenesis, whereas at the same time reducing toxicities in treating head and neck squamous cell carcinoma (HNSCC).
- Publication
British journal of cancer, 2010, Vol 103, Issue 12, p1822
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605980