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- Title
Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.
- Authors
Massoner, P; Ladurner-Rennau, M; Eder, I E; Klocker, H
- Abstract
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinical trials concerning the blockage of IGF1R in several types of cancer.
- Publication
British journal of cancer, 2010, Vol 103, Issue 10, p1479
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605932