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- Title
Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib.
- Authors
Lecis, D; Drago, C; Manzoni, L; Seneci, P; Scolastico, C; Mastrangelo, E; Bolognesi, M; Anichini, A; Kashkar, H; Walczak, H; Delia, D
- Abstract
XIAP (X-linked inhibitor of apoptosis protein) is an anti-apoptotic protein exerting its activity by binding and suppressing caspases. As XIAP is overexpressed in several tumours, in which it apparently contributes to chemoresistance, and because its activity in vivo is antagonised by second mitochondria-derived activator of caspase (SMAC)/direct inhibitor of apoptosis-binding protein with low pI, small molecules mimicking SMAC (so called SMAC-mimetics) can potentially overcome tumour resistance by promoting apoptosis.
- Publication
British journal of cancer, 2010, Vol 102, Issue 12, p1707
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605687