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- Title
A novel fragment derived from the beta chain of human fibrinogen, beta43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo.
- Authors
Krajewska, E; Lewis, C E; Chen, Y-Y; Welford, A; Tazzyman, S; Staton, C A
- Abstract
Angiogenesis and haemostasis are closely linked within tumours with many haemostatic proteins regulating tumour angiogenesis. Indeed we previously identified a fragment of human fibrinogen, fibrinogen E-fragment (FgnE) with potent anti-angiogenic properties in vitro and cytotoxic effects on tumour vessels in vivo. We therefore investigated which region of FgnE was mediating vessel cytotoxicity.
- Publication
British journal of cancer, 2010, Vol 102, Issue 3, p594
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605495