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- Title
Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression.
- Authors
Chen, G; Tian, X; Liu, Z; Zhou, S; Schmidt, B; Henne-Bruns, D; Bachem, M; Kornmann, M
- Abstract
Secreted protein acidic and rich in cysteine (SPARC) is a multi-faceted protein-modulating cell-cell and cell-matrix interactions. In cancer, SPARC can be not only associated with a highly aggressive phenotype, but also acts as a tumour suppressor. The aim of this study was to characterise the function of SPARC and its modulation by fibroblast growth factor receptor (FGFR) 1 isoforms in pancreatic ductal adenocarcinoma (PDAC).
- Publication
British journal of cancer, 2010, Vol 102, Issue 1, p188
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605440