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Title
Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.
Authors
Jacobson, B A; De, A; Kratzke, M G; Patel, M R; Jay-Dixon, J; Whitson, B A; Sadiq, A A; Bitterman, P B; Polunovsky, V A; Kratzke, R A
Abstract
Insulin-like growth factor (IGF)-I signalling stimulates proliferation, survival, and invasion in malignant mesothelioma and other tumour types. Studies have found that tumourigenesis is linked to dysregulation of cap-dependent protein translation.
Publication
British journal of cancer, 2009, Vol 101, Issue 3, p424