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- Title
Contribution of BRCA1 germ-line mutations to breast cancer in Greece: a hospital-based study of 987 unselected breast cancer cases.
- Authors
Armaou, S; Pertesi, M; Fostira, F; Thodi, G; Athanasopoulos, P S; Kamakari, S; Athanasiou, A; Gogas, H; Yannoukakos, D; Fountzilas, G; Konstantopoulou, I
- Abstract
In most Western populations, 5-10% of all breast cancer cases can be attributed to major genetic factors such as predisposing mutations in BRCA1 and BRCA2, with early-onset cases generally considered as an indicator of genetic susceptibility. Specific BRCA1 and BRCA2 mutations or different mutation frequencies have been identified in specific populations and ethnic groups. Previous studies in Greek breast and/or ovarian cancer patients with family history have shown that four specific BRCA1 mutations, c.5266dupC, G1738R, and two large genomic rearrangements involving deletions of exons 20 and 24, have a prominent function in the population's BRCA1 and BRCA2 mutation spectrum.
- Publication
British journal of cancer, 2009, Vol 101, Issue 1, p32
- ISSN
1532-1827
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6605115