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- Title
A twist for survival and cancer progression.
- Authors
Puisieux, A; Valsesia-Wittmann, S; Ansieau, S
- Abstract
A major obstacle to the expansion of abnormal cells with significant proliferative potential is the induction of programmed cell death. Consequently, oncogene-driven hyperproliferation must be associated with apoptosis inhibition to allow malignant outgrowth. The oncogenic cooperation of N-Myc and Twist-1 in the development of neuroblastoma, the most common and deadly solid tumour of childhood, perfectly illustrates such a process. N-Myc promotes cell proliferation, whereas Twist-1 counteracts its pro-apoptotic properties by knocking-down the ARF/p53 pathway. On the basis of numerous recent studies reporting its overexpression in a variety of human cancers, we discuss in this review the role of Twist-1 as a potent inhibitor of the cell safety programs engaged in response to an abnormal mitogenic activity.
- Publication
British journal of cancer, 2006, Vol 94, Issue 1, p13
- ISSN
0007-0920
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6602876