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- Title
Risk of breast cancer among users of aspirin and other anti-inflammatory drugs.
- Authors
Rodriguez, L. A. Garcia; Gonzalez-Pérez, A.
- Abstract
We conducted a cohort study with a nested case-control analysis to evaluate the effect of anti-inflammatory drugs in breast cancer incidence using the General Practice Research Database. Women taking aspirin and paracetamol for 1 year or longer had an odds ratio (OR) of 0.77 (95 percent confidence interval (95% CI): 0.62,0.95) and 0.76 (95% CI: 0.65,0.88), respectively, compared to nonusers. Daily doses of aspirin (75?mg) and paracetamol (up to 2000?mg) showed the greatest reduced risk. Use of non-aspirin nonsteroidal anti-inflammatory drugs for more than 1 year was not associated with a reduced risk of breast cancer (OR=1.00 (95% CI: 0.84, 1.17), and the corresponding estimate among users with at least 2 years duration was similar. Our findings suggest that aspirin at cardioprophylactic doses as well as paracetamol at analgesic doses is associated with a reduced risk of breast cancer.British Journal of Cancer (2004) 91, 525-529. doi:10.1038/sj.bjc.6602003 www.bjcancer.com Published online 29 June 2004
- Publication
British Journal of Cancer, 2004, Vol 91, Issue 3, p525
- ISSN
0007-0920
- Publication type
Academic Journal
- DOI
10.1038/sj.bjc.6602003