We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Negative human papillomavirus testing in normal smears selects a population at low risk for developing high-grade cervical lesions.
- Authors
Ciavel, C.; Cucherousset, J.; Lorenzato, M.; Caudroy, S.; Nou, J.M.; Nazeyrollas, P.; Polette, M.; Bory, J-P.; Gabriel, R.; Quereux, C.; Birembaut, P.
- Abstract
High-risk human papillomaviruses (HR-HPV) are the necessary cause of cervical carcinomas and there is an increasing interest in using HR-HPV DNA detection in adjunction to cytological examination for primary cervical screening. To determine whether women with a normal smear negative for HR-HPV DNA detection with the Hybrid Capture II assay might represent a low-risk population for developing a high-grade squamous intraepithelial lesion (HSIL), 4401 women have been followed in a period of 12-72 months (median=34 months). During this follow-up, four HSIL and one microinvasive carcinoma have been detected in this cohort (three in the cohort of 3526 women >29 years). The global negative predictive value (NPV) of double-negative tests is thus of 99.9% (ninety-five percent confidence interval (95% CI): 99.8-100%), whereas cytology alone gives an NPV of 99.2% (95% CI: 98.9-99.5%). If we obtain a second negative HR-HPV test 1-2 years after the initial test, the NPV is 100%. The NPV is also of 100% in the cohort of women >49 years. We conclude that all these women could be safely screened at longer intervals between 3 and 5 years. This policy will offset the increased costs induced by an additional HR-HPV testing in primary screening.British Journal of Cancer (2004) 90, 1803-1808. doi:10.1038/sj.bjc.6601726 www.bjcancer.com Published online 20 April 2004
- Publication
British Journal of Cancer, 2004, Vol 90, Issue 9, p1803
- ISSN
0007-0920
- Publication type
Academic Journal
- DOI
10.1038/sj.bjc.6601726