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- Title
Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes.
- Authors
Cowell, J K; Wang, Y D; Head, K; Conroy, J; McQuaid, D; Nowak, N J
- Abstract
Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of 6000 bacterial artificial chromosomes for array-based comparative genomic hybridisation, which provides an average resolution of 750 kb across the human genome. Using these arrays, subtle gains and losses of chromosome regions can be detected in constitutional cells, following a single overnight hybridisation. In this report, we demonstrate the efficiency of this procedure in identifying constitutional deletions and duplications associated with predisposition to retinoblastoma, Wilms tumour and Beckwith-Wiedemann syndrome.
- Publication
British journal of cancer, 2004, Vol 90, Issue 4, p860
- ISSN
0007-0920
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6601588