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- Title
Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis.
- Authors
Clifford, G M; Smith, J S; Aguado, T; Franceschi, S
- Abstract
Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.
- Publication
British journal of cancer, 2003, Vol 89, Issue 1, p101
- ISSN
0007-0920
- Publication type
Journal Article
- DOI
10.1038/sj.bjc.6601024