We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Integrating developmental signals: a Hippo in the (path)way.
- Authors
Mauviel, A; Nallet-Staub, F; Varelas, X
- Abstract
The Hippo pathway, a signaling cascade that controls cell cycle progression, apoptosis and cell differentiation, has emerged as a fundamental regulator of many physiological and pathological processes. Recent studies have revealed a complex network of interactions directing Hippo pathway activity, and have connected this pathway with other key signaling pathways. Such crosstalk has uncovered novel roles for Hippo signaling, including regulation of TGFβ/SMAD and WNT/β-catenin pathways. This review highlights some of the recent findings in the Hippo field with an emphasis on how the Hippo pathway is integrated with other pathways to mediate diverse processes.
- Publication
Oncogene, 2012, Vol 31, Issue 14, p1743
- ISSN
1476-5594
- Publication type
Journal Article
- DOI
10.1038/onc.2011.363