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- Title
Calcium and apoptosis: ER-mitochondria Ca<sup>2+</sup> transfer in the control of apoptosis.
- Authors
Pinton, P.; Giorgi, C.; Siviero, R.; Zecchini, E.; Rizzuto, R.
- Abstract
There is a growing consensus that the various forms of cell death (necrosis, apoptosis and autophagy) are not separated by strict boundaries, but rather share molecular effectors and signaling routes. Among the latter, a clear role is played by calcium (Ca2+), the ubiquitous second messenger involved in the control of a broad variety of physiological events. Fine tuning of intracellular Ca2+ homeostasis by anti- and proapoptotic proteins shapes the Ca2+ signal to which mitochondria and other cellular effectors are exposed, and hence the efficiency of various cell death inducers. Here, we will review: (i) the evidence linking calcium homeostasis to the regulation of apoptotic, and more recently autophagic cell death, (ii) the discussion of mitochondria as a critical, although not unique checkpoint and (iii) the molecular and functional elucidation of ER/mitochondria contacts, corresponding to the mitochondria-associated membrane (MAM) subfraction and proposed to be a specialized signaling microdomain.Oncogene (2008) 27, 6407–6418; doi:10.1038/onc.2008.308
- Publication
Oncogene, 2008, Vol 27, Issue 50, p6407
- ISSN
0950-9232
- Publication type
Academic Journal
- DOI
10.1038/onc.2008.308