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- Title
A potential role for 5-androstene-3β,7β,17β-triol in obesity and metabolic syndrome.
- Authors
Auci, Dominick L; Ahlem, Clarence N; Kennedy, Michael R; Page, Theodore M; Reading, Christopher L; Frincke, James M
- Abstract
Metabolic syndrome is marked by perturbed glucocorticoid (GC) signaling, systemic inflammation, and altered immune status. Dehydroepiandrosterone (DHEA), a major circulating adrenal steroid and dietary supplement, demonstrates antiobesity, anti-inflammatory, GC-opposing and immune-modulating activity when administered to rodents. However, plasma DHEA levels failed to correlate with metabolic syndrome and oral replacement therapy provided only mild benefits to patients. Androstene-3β,7β,17β-triol (β-AET) an anti-inflammatory metabolite of DHEA, also exhibits GC-opposing and immune-modulating activity when administered to rodents. We hypothesized a role for β-AET in obesity. We now report that plasma levels of β-AET positively correlate with BMI in healthy men and women. Together with previous studies, the observations reported here may suggest a compensatory role for β-AET in preventing the development of metabolic syndrome. The β-AET structural core may provide the basis for novel pharmaceuticals to treat this disease.
- Publication
Obesity (Silver Spring, Md.), 2011, Vol 19, Issue 4, p806
- ISSN
1930-739X
- Publication type
Journal Article
- DOI
10.1038/oby.2010.204