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- Title
Some like it hot: the structure and function of small heat-shock proteins.
- Authors
Haslbeck, Martin; Franzmann, Titus; Weinfurtner, Daniel; Buchner, Johannes
- Abstract
Small heat-shock proteins (sHsps) are a widespread and diverse class of molecular chaperones. Recent evidence suggests that they maintain protein homeostasis by binding proteins in non-native conformations, thereby preventing substrate aggregation. Some members of the sHsp family are inactive or only partially active under physiological conditions, and transition toward the active state is induced by specific triggers, such as elevated temperature. Release of substrate proteins bound to sHsps requires cooperation with ATP-dependent chaperones, suggesting that sHsps create a reservoir of non-native proteins for subsequent refolding.
- Publication
Nature structural & molecular biology, 2005, Vol 12, Issue 10, p842
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb993