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- Title
SRP meets the ribosome.
- Authors
Wild, Klemens; Halic, Mario; Sinning, Irmgard; Beckmann, Roland
- Abstract
Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.
- Publication
Nature structural & molecular biology, 2004, Vol 11, Issue 11, p1049
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb853