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- Title
Regulated nucleosome mobility and the histone code.
- Authors
Cosgrove, Michael S; Boeke, Jef D; Wolberger, Cynthia
- Abstract
Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.
- Publication
Nature structural & molecular biology, 2004, Vol 11, Issue 11, p1037
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb851