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- Title
Evidence that microRNAs are associated with translating messenger RNAs in human cells.
- Authors
Maroney, Patricia A; Yu, Yang; Fisher, Jesse; Nilsen, Timothy W
- Abstract
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3' untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS mRNA), are actively being translated.
- Publication
Nature structural & molecular biology, 2006, Vol 13, Issue 12, p1102
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb1174