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- Title
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
- Authors
Alam, Steven L; Langelier, Charles; Whitby, Frank G; Koirala, Sajjan; Robinson, Howard; Hill, Christopher P; Sundquist, Wesley I
- Abstract
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.
- Publication
Nature structural & molecular biology, 2006, Vol 13, Issue 11, p1029
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb1160