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- Title
Oriented loading of FtsK on KOPS.
- Authors
Bigot, Sarah; Saleh, Omar A; Cornet, François; Allemand, Jean-François; Barre, François-Xavier
- Abstract
In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.
- Publication
Nature structural & molecular biology, 2006, Vol 13, Issue 11, p1026
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb1159