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- Title
Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions.
- Authors
Didiano, Dominic; Hobert, Oliver
- Abstract
We use Caenorhabditis elegans to test proposed general rules for microRNA (miRNA)-target interactions. We show that G.U base pairing is tolerated in the 'seed' region of the lsy-6 miRNA interaction with its in vivo target cog-1, and that 6- to 8-base-pair perfect seed pairing is not a generally reliable predictor for an interaction of lsy-6 with a 3' untranslated region (UTR). Rather, lsy-6 can functionally interact with its target site only in specific 3' UTR contexts. Our findings illustrate the difficulty of establishing generalizable rules of miRNA-target interactions.
- Publication
Nature structural & molecular biology, 2006, Vol 13, Issue 9, p849
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb1138