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Title
Where to start and when to stop.
Authors
Lin Tian; Matouschek, Andreas
Abstract
The article focuses on the regulation of the transcription factors NF-kappa B such as the Drosophila melanogaster Cubitus interruptus and yeast Spt23 and Mga2 through partial protein degradation by the preteasome. A study has shown that the proteasome activates membrane-bound Spt23 and Mga2 by activating their proteolysis at an internal site and degrading the proteins toward both ends of the polypeptide chain.