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- Title
Transcriptional noise and the fidelity of initiation by RNA polymerase II.
- Authors
Struhl, Kevin
- Abstract
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that 90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function.
- Publication
Nature structural & molecular biology, 2007, Vol 14, Issue 2, p103
- ISSN
1545-9993
- Publication type
Journal Article
- DOI
10.1038/nsmb0207-103