We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New insights into ubiquitin E3 ligase mechanism.
- Authors
Berndsen, Christopher E; Wolberger, Cynthia
- Abstract
E3 ligases carry out the final step in the ubiquitination cascade, catalyzing transfer of ubiquitin from an E2 enzyme to form a covalent bond with a substrate lysine. Three distinct classes of E3 ligases have been identified that stimulate transfer of ubiquitin and ubiquitin-like proteins through either a direct or an indirect mechanism. Only recently have the catalytic mechanisms of E3 ligases begun to be elucidated.
- Publication
Nature structural & molecular biology, 2014, Vol 21, Issue 4, p301
- ISSN
1545-9985
- Publication type
Journal Article
- DOI
10.1038/nsmb.2780