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- Title
Releasing the brakes on a chromatin-remodeling enzyme.
- Authors
Manning, Benjamin J; Peterson, Craig L
- Abstract
Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.
- Publication
Nature structural & molecular biology, 2013, Vol 20, Issue 1, p5
- ISSN
1545-9985
- Publication type
Periodical
- DOI
10.1038/nsmb.2482