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- Title
Crystal structure of a monomeric retroviral protease solved by protein folding game players.
- Authors
Khatib, Firas; DiMaio, Frank; Cooper, Seth; Kazmierczyk, Maciej; Gilski, Miroslaw; Krzywda, Szymon; Zabranska, Helena; Pichova, Iva; Thompson, James; Popović, Zoran; Jaskolski, Mariusz; Baker, David; Foldit Contenders Group; Foldit Void Crushers Group
- Abstract
Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.
- Publication
Nature structural & molecular biology, 2011, Vol 18, Issue 10, p1175
- ISSN
1545-9985
- Publication type
Journal Article
- DOI
10.1038/nsmb.2119