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- Title
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site.
- Authors
Batra, Vinod K; Beard, William A; Hou, Esther W; Pedersen, Lars C; Prasad, Rajendra; Wilson, Samuel H
- Abstract
The major product of oxidative base damage is 8-oxo-7,8-dihydro-2'-deoxyguanine (8odG). The coding potential of this lesion is modulated by its glycosidic torsion angle that controls whether its Watson-Crick or Hoogsteen edge is used for base pairing. The 2.0-A structure of DNA polymerase (pol) beta bound with 8odGTP opposite template adenine indicates that the modified nucleotide assumes the mutagenic syn conformation and that the nonmutagenic anti conformation would be incompatible with efficient DNA synthesis.
- Publication
Nature structural & molecular biology, 2010, Vol 17, Issue 7, p889
- ISSN
1545-9985
- Publication type
Journal Article
- DOI
10.1038/nsmb.1852