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- Title
Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.
- Authors
sbreve, Dragana; Miller, Marshall C.; Quinkert, Zachary T.; Stein, Markus; Chait, Brian T.; Stebbins, C. Erec
- Abstract
The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2.
- Publication
Nature Structural & Molecular Biology, 2010, Vol 17, Issue 1, p130
- ISSN
1545-9993
- Publication type
Academic Journal
- DOI
10.1038/nsmb.1705