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- Title
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
- Authors
Gabel, Harrison W; Ruvkun, Gary
- Abstract
The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.
- Publication
Nature structural & molecular biology, 2008, Vol 15, Issue 5, p531
- ISSN
1545-9985
- Publication type
Journal Article
- DOI
10.1038/nsmb.1411