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- Title
All-atom homology model of the Escherichia coli 30S ribosomal subunit.
- Authors
Tung, Chang-Shung; Joseph, Simpson; Sanbonmatsu, Kevin Y
- Abstract
Understanding the structural basis of ribosomal function requires close comparison between biochemical and structural data. Although a large amount of biochemical data are available for the Escherichia coli ribosome, the structure has not been solved to atomic resolution. Using a new RNA homology procedure, we have modeled the all-atom structure of the E. coli 30S ribosomal subunit. We find that the tertiary structure of the ribosome core, including the A-, P- and E-sites, is highly conserved. The hypervariable regions in our structure, which differ from the structure of the 30S ribosomal subunit from Thermus thermophilus, are consistent with the cryo-EM map of the E. coli ribosome.
- Publication
Nature structural biology, 2002, Vol 9, Issue 10, p750
- ISSN
1072-8368
- Publication type
Journal Article
- DOI
10.1038/nsb841