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- Title
The integration of negative affect, pain and cognitive control in the cingulate cortex.
- Authors
Shackman, Alexander J; Salomons, Tim V; Slagter, Heleen A; Fox, Andrew S; Winter, Jameel J; Davidson, Richard J
- Abstract
It has been argued that emotion, pain and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. However, recent observations encourage a fundamentally different view. Imaging studies demonstrate that negative affect, pain and cognitive control activate an overlapping region of the dorsal cingulate--the anterior midcingulate cortex (aMCC). Anatomical studies reveal that the aMCC constitutes a hub where information about reinforcers can be linked to motor centres responsible for expressing affect and executing goal-directed behaviour. Computational modelling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of the dorsal cingulate's contribution to negative affect and pain.
- Publication
Nature reviews. Neuroscience, 2011, Vol 12, Issue 3, p154
- ISSN
1471-0048
- Publication type
Journal Article
- DOI
10.1038/nrn2994