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- Title
How does PKMζ maintain long-term memory?
- Authors
Sacktor, Todd C
- Abstract
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.
- Publication
Nature reviews. Neuroscience, 2011, Vol 12, Issue 1, p9
- ISSN
1471-0048
- Publication type
Journal Article
- DOI
10.1038/nrn2949