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- Title
New insights into symptoms and neurocircuit function of anorexia nervosa.
- Authors
Kaye, Walter H; Fudge, Julie L; Paulus, Martin
- Abstract
Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.
- Publication
Nature reviews. Neuroscience, 2009, Vol 10, Issue 8, p573
- ISSN
1471-0048
- Publication type
Journal Article
- DOI
10.1038/nrn2682