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- Title
Neuronal regulation of alternative pre-mRNA splicing.
- Authors
Qin Li; Ji-Ann Lee; Black, Douglas L.
- Abstract
Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.
- Publication
Nature Reviews Neuroscience, 2007, Vol 8, Issue 11, p819
- ISSN
1471-003X
- Publication type
Academic Journal
- DOI
10.1038/nrn2237