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- Title
Reelin, lipoprotein receptors and synaptic plasticity.
- Authors
Herz, Joachim; Chen, Ying
- Abstract
Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have recently been recognized as pivotal components of the neuronal signalling machinery. The interaction between APOE receptors and one of their ligands, reelin, allows them to function directly as signal transduction receptors at the plasma membrane to control not only neuronal positioning during brain development, but also synaptic plasticity in the adult brain. Here, we review the molecular mechanisms through which APOE, cholesterol, reelin and APOE receptors control synaptic functions that are essential for cognition, learning, memory, behaviour and neuronal survival.
- Publication
Nature reviews. Neuroscience, 2006, Vol 7, Issue 11, p850
- ISSN
1471-003X
- Publication type
Journal Article
- DOI
10.1038/nrn2009