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- Title
Adult neurogenesis and functional plasticity in neuronal circuits.
- Authors
Lledo, Pierre-Marie; Alonso, Mariana; Grubb, Matthew S
- Abstract
The adult brain is a plastic place. To ensure that the mature nervous system's control of behaviour is flexible in the face of a varying environment, morphological and physiological changes are possible at many levels, including that of the entire cell. In two areas of the adult brain - the olfactory bulb and the dentate gyrus - new neurons are generated throughout life and form an integral part of the normal functional circuitry. This process is not fixed, but highly modulated, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment. The functional benefits of this whole-cell plasticity, however, remain a matter for debate.
- Publication
Nature reviews. Neuroscience, 2006, Vol 7, Issue 3, p179
- ISSN
1471-003X
- Publication type
Journal Article
- DOI
10.1038/nrn1867