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- Title
Cortical inhibitory neurons and schizophrenia.
- Authors
Lewis, David A; Hashimoto, Takanori; Volk, David W
- Abstract
Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.
- Publication
Nature reviews. Neuroscience, 2005, Vol 6, Issue 4, p312
- ISSN
1471-003X
- Publication type
Journal Article
- DOI
10.1038/nrn1648