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- Title
Stress, cognitive impairment and cell adhesion molecules.
- Authors
Sandi, Carmen
- Abstract
Stress has profound effects on brain structure and function, but the underlying mechanisms are still poorly understood. Recent studies imply that neuronal cell adhesion molecules of the immunoglobulin superfamily--NCAM and L1--are important mediators of the effects of stress on the brain. Chronic stress regimes that lead to hippocampal atrophy and spatial-learning impairment in rodents simultaneously induce a pattern of changes in cell adhesion molecule expression that fits with a role for these molecules in stress-induced neuronal damage and neuroprotective mechanisms. These findings highlight cell adhesion molecules as potential therapeutic targets to treat stress-related cognitive disturbances.
- Publication
Nature reviews. Neuroscience, 2004, Vol 5, Issue 12, p917
- ISSN
1471-003X
- Publication type
Journal Article
- DOI
10.1038/nrn1555