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Title: Structural biology: Activating and guiding Cas9.
Authors: Du Toit, Andrea
Abstract: The article cites a research study by M. Jinek and colleagues published in the journal "Science," which examines structures of Cas9 endonucleases. The CRISPR-Cas adaptive immune systems function in the elimination of foreign nucleic acids. Jinek et al. showed that Cas9 enzyme contain a conserved catalytic core that comprises a nuclease lobe and a variable, alpha-helical lobe.
Subjects: ENDONUCLEASES; IMMUNE system; NUCLEIC acids; JINEK, M.; ENZYMES
Publication: Nature Reviews Microbiology, 2014, Vol 12, Issue 4, p236
ISSN: 1740-1526
Publication type: Academic Journal
DOI: 10.1038/nrmicro3237

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Structural biology: Activating and guiding Cas9.