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- Title
Molecular insight into invasive group A streptococcal disease.
- Authors
Cole, Jason N; Barnett, Timothy C; Nizet, Victor; Walker, Mark J
- Abstract
Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide. The GAS serotype M1T1 clone is the most frequently isolated serotype from life-threatening invasive (at a sterile site) infections, such as streptococcal toxic shock-like syndrome and necrotizing fasciitis. Here, we describe the virulence factors and newly discovered molecular events that mediate the in vivo changes from non-invasive GAS serotype M1T1 to the invasive phenotype, and review the invasive-disease trigger for non-M1 GAS. Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases.
- Publication
Nature reviews. Microbiology, 2011, Vol 9, Issue 10, p724
- ISSN
1740-1534
- Publication type
Journal Article
- DOI
10.1038/nrmicro2648