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- Title
Shifting the balance: antibiotic effects on host-microbiota mutualism.
- Authors
Willing, Benjamin P; Russell, Shannon L; Finlay, B Brett
- Abstract
Antibiotics have been used effectively as a means to treat bacterial infections in humans and animals for over half a century. However, through their use, lasting alterations are being made to a mutualistic relationship that has taken millennia to evolve: the relationship between the host and its microbiota. Host-microbiota interactions are dynamic; therefore, changes in the microbiota as a consequence of antibiotic treatment can result in the dysregulation of host immune homeostasis and an increased susceptibility to disease. A better understanding of both the changes in the microbiota as a result of antibiotic treatment and the consequential changes in host immune homeostasis is imperative, so that these effects can be mitigated.
- Publication
Nature reviews. Microbiology, 2011, Vol 9, Issue 4, p233
- ISSN
1740-1534
- Publication type
Journal Article
- DOI
10.1038/nrmicro2536