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- Title
Pyroptosis: host cell death and inflammation.
- Authors
Bergsbaken, Tessa; Fink, Susan L; Cookson, Brad T
- Abstract
Eukaryotic cells can initiate several distinct programmes of self-destruction, and the nature of the cell death process (non-inflammatory or proinflammatory) instructs responses of neighbouring cells, which in turn dictates important systemic physiological outcomes. Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by various pathological stimuli, such as stroke, heart attack or cancer, and is crucial for controlling microbial infections. Pathogens have evolved mechanisms to inhibit pyroptosis, enhancing their ability to persist and cause disease. Ultimately, there is a competition between host and pathogen to regulate pyroptosis, and the outcome dictates life or death of the host.
- Publication
Nature reviews. Microbiology, 2009, Vol 7, Issue 2, p99
- ISSN
1740-1534
- Publication type
Journal Article
- DOI
10.1038/nrmicro2070