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- Title
Opinion: Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study.
- Authors
Krulwich, Terry A.; Lewinson, Oded; Padan, Etana; Bibi, Eitan
- Abstract
Drug and multidrug resistance have greatly compromised the compounds that were once the mainstays of antibiotic therapy. This resistance often persists despite reductions in the use of antibiotics, indicating that the proteins encoded by antibiotic-resistance genes have alternative physiological roles that can foster such persistence in the absence of selective pressure by antibiotics. The recent observations that Tet(L), a tetracycline-efflux transporter, and MdfA, a multidrug-efflux transporter, both confer alkali tolerance offer a striking case study in support of this hypothesis.
- Publication
Nature Reviews Microbiology, 2005, Vol 3, Issue 7, p566
- ISSN
1740-1526
- Publication type
Academic Journal
- DOI
10.1038/nrmicro1181