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- Title
Insights into host responses against pathogens from transcriptional profiling.
- Authors
Jenner, Richard G; Young, Richard A
- Abstract
DNA microarrays have allowed us to monitor the effects of pathogens on host-cell gene expression programmes in great depth and on a broad scale. The comparison of results that have been generated by these studies is complex, and such a comparison has not previously been attempted in a systematic manner. In this review, we have collated and compared published transcriptional-profiling data from 32 studies that involved 77 different host-pathogen interactions, and have defined a common host-transcriptional-response. We outline gene expression patterns in the context of Toll-like receptor and pathogen-mediated signalling pathways, and summarize the contributions that transcriptional-profiling studies have made to our understanding of the infectious disease process.
- Publication
Nature reviews. Microbiology, 2005, Vol 3, Issue 4, p281
- ISSN
1740-1526
- Publication type
Journal Article
- DOI
10.1038/nrmicro1126