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- Title
Iron and microbial infection.
- Authors
Schaible, Ulrich E; Kaufmann, Stefan H E
- Abstract
The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. It is also a pivotal component of the innate immune response through its role in the generation of toxic oxygen and nitrogen intermediates. During evolution, the shared requirement of micro- and macroorganisms for this important nutrient has shaped the pathogen-host relationship. Here, we discuss how pathogens compete with the host for iron, and also how the host uses iron to counteract this threat.
- Publication
Nature reviews. Microbiology, 2004, Vol 2, Issue 12, p946
- ISSN
1740-1526
- Publication type
Journal Article
- DOI
10.1038/nrmicro1046