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- Title
Genome-scale models of microbial cells: evaluating the consequences of constraints.
- Authors
Price, Nathan D; Reed, Jennifer L; Palsson, Bernhard Ø
- Abstract
Microbial cells operate under governing constraints that limit their range of possible functions. With the availability of annotated genome sequences, it has become possible to reconstruct genome-scale biochemical reaction networks for microorganisms. The imposition of governing constraints on a reconstructed biochemical network leads to the definition of achievable cellular functions. In recent years, a substantial and growing toolbox of computational analysis methods has been developed to study the characteristics and capabilities of microorganisms using a constraint-based reconstruction and analysis (COBRA) approach. This approach provides a biochemically and genetically consistent framework for the generation of hypotheses and the testing of functions of microbial cells.
- Publication
Nature reviews. Microbiology, 2004, Vol 2, Issue 11, p886
- ISSN
1740-1526
- Publication type
Journal Article
- DOI
10.1038/nrmicro1023