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- Title
Sorting out the cellular functions of sorting nexins.
- Authors
Worby, Carolyn A; Dixon, Jack E
- Abstract
Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif - the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
- Publication
Nature reviews. Molecular cell biology, 2002, Vol 3, Issue 12, p919
- ISSN
1471-0072
- Publication type
Journal Article
- DOI
10.1038/nrm974