We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
TRANSCRIPTION: MAPK-REGULATED TRANSCRIPTION: A CONTINUOUSLY VARIABLE GENE SWITCH?
- Authors
Hazzalin, Catherine A.; Mahadevan, Louis C.
- Abstract
Switching mechanisms that control genes could be viewed either as stable binary switches, in which genes exist in 'on' or 'off' states; or as quantitative rheostat-like switches, in which the rate of transcription is continuously variable and coupled directly to the strength of intracellular signalling events. Here, we discuss the biological need for quantitative gene regulation and, using mitogen-activated protein kinase (MAPK)-controlled transcription as a model, assess the evidence for its existence and postulate mechanisms by which it might occur.
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 1, p30
- ISSN
1471-0072
- Publication type
Academic Journal
- DOI
10.1038/nrm715